The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

摘要

Recent evidence has shown that the chemerin receptor 23 (ChemR23) represents a novel inflammatorypain target, whereby the ChemR23 agonists, resolvin E1 and chemerin, can inhibit inflammatory painhypersensitivity, by a mechanism that involves normalisation of potentiated spinal cord responses.This study has examined the ability of the ChemR23 agonist, chemerin, to modulate synaptic inputto lamina I neurokinin 1 receptor expressing (NK1R+) dorsal horn neurons, which are known to becrucial for the manifestation of inflammatory pain.